DECCACEF

cefuraxime axetil Introduction

Cefuroxime Axetil , Deccacef  is a second-generation cephalosporin antibiotic. It is a broad-spectrum antibiotic, meaning it is effective against a wide variety of bacteria. It works by disrupting the formation of the bacterial cell wall, ultimately killing the bacteria.

Indications (Uses)

It is prescribed to treat bacterial infections, including:

• Respiratory Infections: Pharyngitis (sore throat), tonsillitis, sinusitis, and acute bronchitis.

• Ear Infections: Otitis media (middle ear infection).

• Skin Infections: Uncomplicated skin and soft tissue infections (e.g., impetigo).

• Urinary Tract Infections (UTIs): Early-stage or uncomplicated bladder infections.

• Lyme Disease: Early-stage Lyme disease (erythema migrans).

• Gonorrhea: Uncomplicated gonorrhea (often as a single dose).

Dosage Guidelines

Always follow the specific instructions on your prescription label.

• Adults: Typically 250 mg or 500 mg taken orally every 12 hours. Duration usually ranges from 5 to 10 days, though Lyme disease treatment lasts 20 days.

• Children: Dosage is usually calculated by weight (e.g., 20–30 mg/kg/day) divided into two doses.

• How to Take:

  • Tablets: Swallow whole (do not crush due to bitter taste). Absorption is significantly better when taken with food.

  • Suspension: Must be taken with food. Shake well before measuring.

Benefits

• Resistance Fighter: It is stable against many beta-lactamases (enzymes produced by bacteria to resist antibiotics), making it effective where some penicillins might fail.

• Convenience: The twice-daily dosing schedule is easier to remember than antibiotics requiring 3–4 doses per day.

• Versatility: Treats both Gram-positive and Gram-negative bacteria effectively.

Cautions

• Allergies: Do not take if you are allergic to cephalosporins. Use extreme caution if you have a severe penicillin allergy (cross-reactivity can occur).

• Kidney Function: Dosage adjustments may be required for patients with renal impairment.

• Gut Health: Patients with a history of colitis should use this drug with caution.

• Phenylketonuria (PKU): The liquid suspension form may contain phenylalanine.

Drug-Drug Interactions

• Antacids & Acid Reducers: Drugs that reduce stomach acid (like PPIs or H2 blockers) can lower the absorption of Cefuroxime. Take Cefuroxime at least 1 hour before or 2 hours after antacids.

• Oral Contraceptives: May decrease the effectiveness of birth control pills. Use a backup non-hormonal method during treatment.

• Probenecid: Increases the levels of Cefuroxime in the blood (sometimes used intentionally for this effect).

• Blood Thinners: Can affect blood clotting parameters; monitoring may be needed if taking Warfarin.

Side Effects

• Common:

  • Diarrhea / Loose stools

  • Nausea or vomiting

  • Vaginal yeast infections (due to disruption of normal flora)

  • Bitter taste in mouth

• Serious (Seek medical help):

  • Severe Allergic Reaction: Hives, swelling of the face/throat, difficulty breathing.

  • C. Difficile Colitis: Severe, watery, or bloody diarrhea with abdominal cramping (can occur weeks after treatment ends).

  • Severe Skin Rash: Peeling or blistering skin